It teaches you to root for the villain of the house. Most family anime park a sweet grandmother in the corner to dispense wisdom; this one hands her the whole show and lets her torment her son-in-law, needle her daughter, con the grandkids and rope the entire neighborhood into her schemes, then ends the segment before anyone gets a lesson. It comes from Machiko Hasegawa, the same pen behind Sazae-san, and that's the joke: identical warm domestic setup, same four-panel gag rhythm, except the old woman at the center is the weather system everyone else has to survive. No spectacle, no arcs, no growth. Just short, mean, perfectly timed little bits stacked 46 episodes deep. Slept on hard, and anyone who has ever had a relative who enjoys being difficult will recognize her instantly.
Grandma is a nasty, manipulative old woman who spends most of her time stirring up trouble for the people around her. Her son-in-law and her daughter bear the brunt of it, but her grandchildren and the neighbors are hardly spared either. The humor comes from watching everyone deal with her endless meddling. Across 46 episodes, the show plays everyday family friction for laughs as a slice-of-life comedy.