This show doesn't pretend to be anything other than what it is: combat pornography where a genetically engineered girl tears people apart with animal instincts, and the animation budget backs up every second of it. The fights are uncensored, the gore is real, and the heavy metal soundtrack doesn't apologize for what you're watching. You either accept the premise completely or you don't; there's no middle ground, and that's the entire point.
Yuuya expects an ordinary night driving for hire until his car becomes a kidnapping vehicle. The passenger, a high school girl named Hitomi, responds by slaughtering the perpetrators with animalistic brutality. She drags Yuuya to an underground arena where genetically modified fighters called Therianthropes compete in lethal matches. Hitomi is one of them, engineered with honey badger DNA, and she bets Yuuya's organs on her own victory. When she wins decisively, Yuuya finds himself trapped in her world, forced to support a girl who thinks nothing of mauling opponents. The fighting is visceral and unrelenting. Bodies burst apart. Blood saturates every match. Hitomi herself oscillates between childlike curiosity and predatory savagery, treating humans as either toys or obstacles. Yuuya must navigate this brutal ecosystem where he's both indispensable and utterly expendable, constantly on edge around someone who could tear him apart without hesitation. This is for viewers who want action without mercy, where the protagonist has no power except proximity to something dangerous.