The opening stab, your mother murdering you before she dies, isn't a plot twist, it's the show asking if you'll stay when nothing makes sense yet. The animation drowns you in stained glass and gothic shadow so deliberate it feels like watching a fever dream rendered in oil paint. By episode six, the confusion stops being a bug and becomes the point: you're watching someone piece together who they actually are, and the story shifts shape every time Kyosuke gets closer to the truth.
After a disease wipes out the human colony on the moon, Kyosuke Date and his mother escape to Earth and hide in a cathedral, where she poses as a nun. When dangerous people find them, she stabs him, and she is then killed herself. Kyosuke wakes days later, alive, in the home of a girl who says she is Runa, his twin sister. Runa's soul was split into several pieces, creating flicker girls that the Kirihara Group is hunting. Kyosuke survived because his DNA adapted to the disease, and he can now become a monstrous mutant called the SoulTaker. Hunted by both the Hospital and the Kirihara Group, he fights to protect Runa and to learn why his mother did what she did. The series is a supernatural action horror story.